AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
نویسندگان
چکیده
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of medical primatology
دوره 39 5 شماره
صفحات -
تاریخ انتشار 2010